Gamete intrafallopian transfer (GIFT) and zygote intrafallopian transfer (ZIFT) are two methods to help a woman become pregnant. With GIFT, sperm and eggs are put in a fallopian tube. With ZIFT, the sperm and egg are first combined in a lab. Then a fertilized egg is put into a fallopian tube.

Cross section of uterus showing GIFT. Laparoscopic instrument is releasing sperm and eggs into open end of fallopian tube. Label reads: With GIFT, sperm and eggs are placed in a fallopian tube to allow fertilization in the natural site. The woman must have at least one normal, open fallopian tube. Inset of sperm and eggs in lab dish with label: Sperm and eggs are placed into a fallopian tube.

Why GIFT and ZIFT Are Used

GIFT and ZIFT can help cause a pregnancy when some health problems are present. These include:

  • Mild endometriosis and sperm antibodies in a woman

  • Low sperm production in a man

  • Unexplained infertility

Preparation for GIFT or ZIFT

  • Medication is used to stimulate the ovaries. This causes them to make many mature eggs.

  • The eggs are removed from the ovaries with a thin needle. This may be done through the vagina. Or it may be done with a thin, lighted tube (laparoscope).

Hormone Treatment with GIFT or ZIFT

GIFT or ZIFT may be used with hormone treatment. This can improve the chance of a pregnancy. Your doctor can talk with you about the details, success rates, and costs.